Receptor-mediated Endocytosis of CC-chemokines

Receptor-mediated endocytosis of CC-chemokines.

Chemokines are chemotactic proteins which play a central role in immune and inflammatory responses. Chemokine receptors are members of the seven transmembrane G-protein coupled family and have recently been shown to be involved in the entry of human immunodeficiency virus (HIV) into target cells. To study chemokine endocytosis in detail we have used novel site-specific chemistry to make a fluor...

Receptor-mediated endocytosis.

Synergy between coproduced CC and CXC chemokines in monocyte chemotaxis through receptor-mediated events.

CC and CXC chemokines coinduced in fibroblasts and leukocytes by cytokines and microbial agents determine the number of phagocytes infiltrating into inflamed tissues. Interleukin-8/CXCL8 and stromal cell-derived factor-1/CXCL12 significantly and dose-dependently increased the migration of monocytes, expressing the corresponding CXC chemokine receptors CXCR2 and CXCR4, toward suboptimal concentr...

Receptor - mediated endocytosis

In 1934, Lewis described the process ofpinocytosis an invagination of the plasma membrane enclosing a small droplet of fluid. Pinocytosis appeared to be a constitutive process, whereas phagocytosis described some years earlier by Metchnikoffwas regulated. Only within the last two decades has it been recognized that (i) during pinocytosis cells internalize vast amounts of membrane. indeed, more ...

Mechanics of receptor-mediated endocytosis.

Most viruses and bioparticles endocytosed by cells have characteristic sizes in the range of tens to hundreds of nanometers. The process of viruses entering and leaving animal cells is mediated by the binding interaction between ligand molecules on the viral capid and their receptor molecules on the cell membrane. How does the size of a bioparticle affect receptor-mediated endocytosis? Here, we...